What is the difference between eletriptan and sumatriptan

Patients with frequent nonmigrainous headache, atypical migraine that had not previously responded to therapy, migraine with prolonged aura, familial hemiplegic migraine, basilar migraine, or migrainous infarction were excluded from the trial. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials. Pfizer's Upjohn has merged with Mylan to form Viatris Inc. More Information. Additional Information: To obtain contact information for a study center near you, click here. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Migraine With or Without Aura. Phase 3. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Study Start Date :. The benefit of eletriptan 20 mg when compared to sumatriptan 50 mg is greatest around 1. No significant difference was found between eletriptan 20 mg and sumatriptan 50 mg for the fraction of patients that became pain free.

No significant effect of encapsulation of sumatriptan was found on the time course of response up to 4 h after treatment when compared to commercial sumatriptan. Abstract A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan for the proportion of patients that achieve migraine pain relief up to 4 h after treatment.

Because of this, it is referred to as the first-generation triptan. This drug comes in many formulations, and it can be administered orally, via nasal inhalation, skin injection, or application of a skin patch. Sumatriptan is an analog of serotonin, which causes activation of serotonin receptors that are located in the blood vessels of the brain. Sumatriptan does not activate other serotonin receptors, and it also does not have any affinity for other neutrotransmitter receptors in the brain.

Because of this, Sumatriptan is able to relieve migraine headaches through vascular constriction and control of inflammatory molecules. The formulation of Sumatriptan, which has the fastest onset of action, is via subcutaneous injection, which takes effect within 15 minutes of drug administration.

In comparison to orally and intranasally prepared formulations, which are expected to take effect within a range of 20 minutes to an hour. The peak of headache relief can be achieved within a period of two hours for intranasal and subcutaneously injected formulations, while orally administered Sumatriptan has a peak clinical effect after four hours from the time of drug administration.

Eletriptan Relpax is the most recently marketed serotonin agonist for migraines. Compared to Sumatriptan, Eletriptan is considered a second-generation triptan, together with Naratriptan, Rizatriptan, Zolmitriptan, and Frovatriptan. It is only available in an oral formulation, whereas Sumatriptan can be administered by several routes. However, its oral bioavailability is better than Sumatriptan, enabling it to have a faster time to achieve a peak clinical effect on relief of pain.

After oral administration of Eletriptan, peak effect is expected to be noticeable within 90 minutes, compared to Sumatriptan, which has the earliest peak of action within 2 hours after drug administration. Moreover, Eletriptan is metabolized in the liver by a specific enzyme called, cytochrome P3A4. Several drugs, such as Ketocoazole, Itraconazole, Ritonavir, and Clarithromycin, inhibit this enzyme.

Because of these, Eletriptan cannot be co-administered with these medications in order to avoid unwanted side effects. Several research studies show that Eletriptan has a comparable clinical efficacy to Sumatriptan in pain relief during acute migraine attacks, making it a popular treatment choice for migraines.

Both Sumatriptan Imitrex and Eletriptan Relpax can be used to relieve headaches in an acute migraine attack. Sumatriptan is available in several drug formulations and can be administered orally, intranasally, or through skin injection.

On the other hand, Eletriptan is only available in an oral formulation. Despite this, Eletriptan carries the advantage of having an earlier peak of action at 90 minutes than Sumatriptan.

Eletriptan is metabolized by cytochrome P3A4, which is why it should not be administered with medications that interfere with its enzymatic activity. Both medications are equally effective, and treatment selection is usually based on individual responses to these medications for acute migraine attacks.